 |
Torcetrapib and Rimonabant-Acomplia: Promising Next-Generation "Good" Cholesterol Raising Drugs
Generics24.com - Online Pharmacy |
Generic Viagra |
Kamagra Oral Jelly |
Generic Cialis |
Generic Levitra |
ED Trial Pack |
Generic Propecia |
Generic Proscar |
Generic Avodart |
Generic Acomplia |
Generic Xenical |
Generic Zyban |
Generic Imitrex
New York (PRWEB) November 17, 2006 -- Based on compelling evidence that raising high-density lipoprotein cholesterol levels (HDL-C, also known as "good" cholesterol) helps halt atherosclerosis, pharmaceutical companies are racing to produce the next generation of medications to replace the ineffectual ones currently on the market. Niacin, the current drug of choice, increases HDL-C by only 15% to 35%, and then only at daily doses three grams or higher, increasing the chance for unpleasant side effects.
Today at the 33rd annual VEITHsymposium™, Dr. Russell H. Sampson, former Associate Professor of Surgery at the Albert Einstein College of Medicine (Bronx, NY) and current President of Mote Vascular Foundation, Inc. (Sarasota, FL), provided a comprehensive overview of the current state of good cholesterol-raising drugs, including two of the more promising ones, Torcetrapib and Rimonabant-Acomplia.
Torcetrapib (discovered and developed by Pfizer), is a cholesteryl ester transfer protein (CETP) inhibitor. In theory, by blocking CETP it should be possible to improve the ratio of HDL-C to low-density lipoprotein cholesterol (LDL-C, also known as "bad" cholesterol), thus slowing the development and progression of atherosclerosis. Early Phase 2 data published in April 2004 showed that inhibiting CETP with torcetrapib at 120 mg per day produced significant increases in HDL-C when given alone (46%), as well as in combination with Lipitor (61%). When the dosage of torcetrapib was increased to 240 mg per day, HDL-C increased by over 100%. However, patients taking 60 mg of torcetrapib with Lipitor also experienced an increase in systolic blood pressure, a drawback which may outweigh the benefit of raised HDL-C. It is currently estimated
that Torcetrapib will be in the U.S. market in 2008.
Rimonabant-Acomplia (discovered and developed by Sanofi-Aventis) is a CB1 endocannabinoid receptor antagonist. CB1 blockers act on the endocannabinoid system, a system controlling energy and nicotine dependence, reducing the overstimulation thought to lead to obesity and nicotine addiction. In a recent study, 1,036 overweight or obese patients with blood lipid disorders were randomly placed in one of three groups (placebo vs. 5 mg or 20 mg per day of Rimonabant-Acomplia). After one year of treatment, patients receiving 20 mg per day of Rimonabant-Acomplia lost an average of 20 pounds, compared to only 5 pounds for patients on placebo. Further comparisons between the placebo and 20 mg per day Rimonabant-Acomplia group showed that the latter patients enjoyed significant improvements in waist circumference and HDL-C and triglyceride levels, all important factors in maintaining heart health. The drug was said to be well tolerated, with only mild and transient side effects like dizziness and gastrointestinal distress. The drug is currently only approved for sale in Europe, with a date for U.S. availability still uncertain.
Dr. Samson said, "We are about to see a whole new generation of medications to help control atherosclerosis the leading cause of death and disability in the USA and most industrial nations. Current medications may halt or slow down progression, however, it is predicted that these medications may revolutionize treatment by actually reversing this disease that is responsible for heart attack, stroke, and amputations. I am extremely excited by the prospect."
About VEITHsymposium™
Now entering its fourth decade, VEITHsymposium™ provides vascular surgeons, interventional radiologists, interventional cardiologists and other vascular specialists with a unique and exciting format to learn the most current information about what is new and important in the treatment of vascular disease. The 5-day event features 300 rapid-fire presentations from the world's most renowned vascular specialists with emphasis on the latest advances, changing concepts in diagnosis and management, pressing controversies and new techniques.
###
This press release has been reprinted from PRWEB per the terms and conditions of the copyright notice.
|
 |
The Success Rate for Propecia - An Introduction
What is Propecia?
Would You Buy Levitra, Viagra or Cialis for Oral Erectile Dysfunction Medication - A Case Study
Background to Erectile Dysfunction:
Better Sex life with Viagra
Erectile dysfunction, also known as impotence, is the inability to develop or maintain an erection of the penis for satisfactory sexual intercourse regardless of the capability of ejaculation. There are various underlying causes, many of which are medically reversible. It has been estimated that impotence affects 140 million men worldwide.
UK Government in Trouble for Prescribing Generics
Usually it is big pharma giving financial incentives to doctors to sway what type of medication they prescribe, but now big pharma has found itself in our shoes and doesn?t seem to like it to much.
All you have to know about Viagra
Impotence is not a normal issue. People don?t talk about it too much, feeling afraid to hurt the feelings of the affected person. Impotence, also known as sexual dysfunction, happens because of reduced blood flow to the penis, but every case is individual. It varies between different men; some of them have problems from time to time, others more frequently.
Erectile Dysfunction and Kamagra
Men suffer from erectile dysfunction although there is not a man out there who likes to think about it. It is just a natural occurrence that can happen due to psychological or physical reasons and men should realize there are drugs available to help them with their erection problems. One of these drugs is kamagra. Kamagra is a phosphodiesterase inhibitor and it works simply because it allows a man to get an erection and keep it throughout the act of lovemaking. There are many other erectile dysfunction drugs on the market as well like Viagra, penegra, caverta, and more. There are generic versions of name brand drugs that cost significantly less than the other drugs and allow men to affordably handle their erection problems.
Acne Medicines - Do They Work?
If you're like most people suffering from acne, you've probably tried more than one over the counter solution. And you've probably found that most of them don't work, either. Sometimes it can seem like the crop of pimples on your face just never goes away. It's sad but true; most of the acne medications that are readily available don't actually work. Some might even aggravate your skin, which can make the acne worse - which is definitely not why you bought the medication! Maybe it's time to try doing things a little differently.
Rimonabant (Acomplia/Zimulti) Weight Loss Drug
Rimonabant (Acomplia), the new age weight loss drug is developed by world's third largest French pharmaceutical Sanofi-Aventis, to help ever growing number of obese population across the world. Rimonabant is sold under brand name of Acomplia in Europe and under the name as Zimulti in USA. Accomplia (Remonabant) is a new weight loss drug manufactured by Sanofi french pharma company. Remonabant Accomplia helps for the treatment of obesity. Remonabant accomplia works by blocking CB1 receptors which ultimately makes person less hungry. This Drug Accomplia Remonabant is also known as Miracle drug as it helps people to lose weight and acts as Anti-Munchie Drug. Acomplia Remonabant may also help reduce the level of fats in the blood. Rimonabant ...
Benefits of 24X7 Pharmacy
Timely medication helps in saving ones life and providing warding off fatal health complications. Well, bad heath or disease does not happen by chance but can strike any point of time. In such situation, it is extremely important to have proper and timely medication that helps in saving ones life. In case one finds a medical emergency in the middle of the night and is unable to find medical assistance, it can be a nightmarish event. So, for all those who are looking forward to timely medication and health support, 24X7 Pharmacy (www.24x7pharmacy.com) is one of the well known Internet pharmacy, mail order pharmacy, buying generic cialis, buy discount cialis, that is also popular as ...
Bangor's TrimSpa X32 Spokesmodel and Weightloss Success Story to Walk 60 Miles in Three Days in Boston Breast Cancer 3-Day
Bangor,Maine -Walker Encourages Local Residents to Help Raise Funds for the Susan G. Komen Breast Cancer Foundation and the National Philanthropic Trust Breast Cancer Fund
Get treatment for Impotence with Cialis Tadalafil
Cialis (Tadalafil) Male impotence treatment
Piribo: New Report says Global Generics Market Will Hit US$155.7 billion by 2011
Piribo, the online destination for business intelligence for the biotech and pharmaceutical industry, has now added a new report which finds that the global generics market is predicted to reach US$155.7 billion by 2011.
How to Predict the Future of the European Generics Market: eyeforpharma Announces Guillermo Hartwig of Afarma will Now be in Berlin to Answer This Que
Essential is an overused word, but predicting the future of the European generics market is certainly essential to the success of companies in this highly competitive landscape. Even the slightest edge is welcome, and some thought leaders in the industry are willing to help you get it.
Cialis ? Can it be Dangerous?
Cialis is a wonderful erectile dysfunction treatment drug; however you need to be very careful before you buy Cialis online from Cialis Pharmacy. Let?s look closely at some of its widely known effects and precautions.
Problems With Weightloss Pills!
Weight loss pills have been around for decades now They have been falling in and out of favor as a method to lose weight for so long that, whenever a new weight loss pill is approved by the FDA and enters the market, no one really gives it a second thought
|
